Dr. Malcolm Binns
- Biostatistics
Research Focus
My primary role at the Rotman Research Institute is to pursue collaborative research, integrating biostatistical methodology into multidisciplinary studies of human brain function. The overarching goal of my work is to explore the utility of statistical methods in generating knowledge about the human brain from complex data. Many measures of human brain physiology and function are distributed with specific patterns that may not match the theoretical foundations of many statistical methods. I investigate the impact of these discrepancies on the applicability of quantitative methods such as linear models for practical bedside tests of the ability to learn new information. I lead investigations into the implications of specific data patterns for indices that guide interpretation of multivariate covariance models and for measurements of distance for multivariate observations lying outside the rest of the sample. Another trajectory of my research targets characterization of changes in brain function using discrete multivariate methods as well as those underpinned by continuous functions.
Select Publications
- Sunderland KM, Beaton D, Fraser J, Kwan D, McLaughlin PM, Montero-Odasso M, Peltsch AJ, Pieruccini-Faria F, Sahlas DJ, Swartz RH, Strother SC, Binns MA. (2019). The utility of multivariate outlier detection techniques for data quality evaluation in large studies: an application within the ONDRI project. BMC MEDICAL RESEARCH METHODOLOGY, 19, 102.
- Bialystok E, Craik FIM, Binns MA, Ossher L. (2014). Effects of Bilingualism on the Age of Onset and Progression of MCI and AD: Evidence From Executive Function Tests. NEUROPSYCHOLOGY, 28, 290-304.
- Winocur G, Henkelman M, Wojtowicz JM, Zhang HB, Binns MA, Tannock, IF. (2012). The Effects of Chemotherapy on Cognitive Function in a Mouse Model: A Prospective Study. CLINICAL CANCER RESEARCH, 18, 3112-3121.
- Kim ASN, Binns MA, Alain C. (2012). Neuroelectric Evidence for Cognitive Association Formation: An Event-Related Potential Investigation. PLoS ONE, 7(4), e34856.
