Research Focus

Normal brain function is predicated upon a continuous neuronal and vascular interplay, a mechanism that is likely to deteriorate during the cognitive decline associated with aging as well as neurological disorders. Despite previous research efforts, the causes of aging-related illnesses such as dementia remain unclear, and the key to preventative treatment elusive. My research is driven by the need to better understand disease mechanisms by using neuroimaging to observe the living brain. My research is focused on functional magnetic resonance imaging (fMRI) methodological development, physiological modeling, and the application of our methods in characterizing diseases/treatments. Specifically, we are interested in: 1) Functional MRI methodological development, 2) Measurement of cerebral perfusion and metabolism using MRI techniques, 3) Measurement of tissue microstructure using diffusion-weighted MRI, 4) Investigating the relationship between functional and structural brain changes in neurodegenerative diseases.

Select Publications

• Srisaikaew P, Chad JA, Mahakkanukrauh P, Anderson ND, Chen JJ. (2023). Effect of sex on the APOE4-aging interaction in the white matter microstructure of cognitively normal older adults. Frontiers in Neuroscience, 17, 1049609.
• Chad JA, Pasternak Oand Chen JJ. (2021). Orthogonal diffusion tensor decomposition reveals age-related degeneration patterns in complex fibre architecture. . Neurobiol Aging
• Attarpour A, Ward Jand Chen JJ. (2021). Vascular origins of low-frequency oscillations in the cerebrospinal fluid signal in resting-state fMRI: validation using photoplethysmography. Hum Brain Mapp
• Srisaikaew P, Wongparakaran N, Anderson ND, Chen JJ, Kothan S, Varnado P, Unsrisong K, Mahakkanukrauh P. (2020). Fornix integrity and fibre length as a dementia biomarker: A pilot diffusion tensor imaging study in Thai older adults. . Frontiers in Aging Neuroscience, 12, 594002.

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Curriculum Vitae

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