Dr. Sandra Black
Dr. Sandra Black

Available Translations

Dr. Sandra Black, MD, FRCP(C)

Neuroscience Program Research Director Sunnybrook Research Institute

Brill Chair in Neurology Dept of Medicine, University of Toronto

Professor Dept of Medicine (Neurology), University of Toronto

Research Focus

As a clinician scientist, I study neurological degeneration and regenerative processes at the integrative level. Specifically, my clinical research has focussed on the cognitive sequelae of stroke and stroke recovery, and the differential diagnosis and monitoring of dementia utilizing concurrent clinical, neuropsychological and neuroimaging measures. I have led multidisciplinary teams in conducting large-group prospective studies with a longitudinal design and labour-intensive acquisition of complex, multidimensional databases. Correlative quantitative neuroimaging provides insight into the biological constraints which are operative in disease progression or recovery. Such information is becoming increasingly important as new treatments come on line for stroke and for dementia, especially given rapid therapeutic advances in neurology in the last decade. It is becoming increasingly evident that Alzheimer’s and Cerebrovascular Disease frequently co-occur in older individuals and have synergistic effects on the clinical expression of dementia. This has beomce a major focus of our research efforts.

An active investigator in clinical trials for dementia and stroke for over 20 years, I have recently been a lead investigator for trials in Vascular Dementia, Severe Alzheimer's Disease and a disease modifying trial for Alzheimer's Disease.

In addition to these clinical studies I also have used experimental approaches aimed primarily at understanding mechanisms which underlie deficits in praxis, visual-spatial function, language, and attention in stroke and in Alzheimer’s Disease (AD). Using both single-case and group-study designs, I collaborate with leading cognitive neuropsychologists to address theoretical issues in brain-behaviour relationships. In these researches, selective vulnerability of degenerative processes and focal injury from stroke provide naturalistic models of ablation and adaptation in the human brain.

Publications

633 publications in total

Education

  • 1978: M.D., Medicine, University of Toronto Ontario, Canada
  • 1970: M.A. equivalent, History and Philosophy of Science, Oxford University
  • 1969: B.Sc., University of Toronto Ontario, Canada

Academic Appointments

  • 2008–Present: Adjunct Scientist, Toronto Rehabilitation Institute
  • 2006–Present: Neuroscience Program Research Director, Sunnybrook Research Institute
  • 2006–Present: Brill Chair in Neurology, Dept of Medicine, University of Toronto
  • 2003–Present: Scientist, Dept of Rehabilitation Sciences, University of Toronto
  • 2002–Present: Site Director, Heart and Stroke Foundation Centre for Stroke Recovery
  • 2001–Present: Medical Director, Regional Stroke Centre, North and East GTA
  • 1999–2010: Senior Scientist, Rotman Research Institute, Baycrest Geriatric Centre, University of Toronto
  • 1999–Present: Professor, Dept of Medicine (Neurology), University of Toronto
  • 1995–2006: Head, Division of Neurology, Sunnybrook Health Sciences Centre, University of Toronto
  • 1994–2010: Member, Neuroscience Program, University of Toronto
  • 1992–1999: Associate Professor, Department of Medicine (Neurology), University of Toronto
  • 1991–1994: Adjunct Assistant Professor, Department of Psychology, University of Waterloo
  • 1991–2010: Member, Institute of Medical Science, University of Toronto
  • 1990–2002: Senior Scientist, Program in Aging/Imaging, Sunnybrook
  • 1990–1999: Associate Scientist, Rotman Research Institute, Baycrest Geriatric Centre, University of Toronto
  • 1988–2010: Co-Director, Stroke Research Unit, Sunnybrook Health Sciences Centre, University of Toronto
  • 1986–2010: Director, Cognitive Neurology Unit, Sunnybrook Health Sciences Centre (As of 2004 renamed LC Campbell Cognitive Neurology Research Unit )
  • 1985–1992: Assistant Professor, Dept of Medicine (Neurology), University of Toronto
  • 1985–2010: Consultant Neurologist, Sunnybrook Health Sciences Centre, ACMS

Reviewership

Consulting

  • 2004: HSFC/CIHR/Alzheimer Society of Canada, Special Competition on Vascular Health and Dementia
  • 2004: Abstract Reviewer for Rotman Research Institute Conference, World Stroke Congress
  • 2002: Abstract Reviewer for Rotman Research Institute Conference, International Neuropsychological Society Meeting
  • 2001–Present: Heart & Stroke Foundation of Ontario, Research & Development Review Committee
  • 1999–2001: Heart & Stroke Foundation of Canada, Scientific Review Committee
  • 1999–2003: Alzheimer Society of Canada, Scientific Review Committee
  • 1997: Medical Research Council (Invitee reviewer)
  • 1999: Medical Research Council (Invitee reviewer)
  • 1997: Medical Research Council Site Review Committee
  • 1997: Ontario Heart & Stroke Foundation Site Review Committee
  • 1996–1999: Heart & Stroke Foundation Scientific Review and Development Committee
  • 1992–1995: Medical Research Council Scientific Review Committee for Behavioural Sciences
  • 1989: Heart & Stroke Foundation of Canada Scientific Review Senior Personnel Committee
  • 1987–1992: Ontario Mental Health Foundation Research Committee
  • 2010: Ad Hoc Reviewer for Agencies (Heart & Stroke Foundation, Canadian Institute of Health Research, Ontario Mental Health Foundation, National Research Council, Alzheimer Society Canada, Canadian Psychiatric Research Foundation, Alberta Heritage Fund, Nova Scotia Health Research Foundation, Alzheimer Association)
  • 2010: Ad Hoc Reviewer for Journals (Canadian Journal of Neurological Sciences, Brain and Language, Neurology, Stroke, Neuropsychologia, Neurocase, Annals of Neurology, Cortex, Journal of International, Neuropsychological Society, Journal Watch, Journal of Rheumatology, Movement Disorders, Cerebral Cortex, Lancet Neurology)
  • 1995: Program Committee Reviewer for International Neuropsychological Society Meeting,
  • 2010–Present: Currently serve on advisory panels for dementia treatment for Pfizer, Janssen-Ortho, Novartis, Lundbeck, and Myriad

Committee

  • 2005–Present: Steering Committee, Canadian Stroke Strategy (
  • 2005–Present: Ontario Stroke Steering Committee
  • 2005: Scientific Program Committee for Vas-Cog 2005 in Florence
  • 2007: Scientific Program Committee for Vas-Cog 2007 San Antonio
  • 2005–2006: Co-Chair, Neuropsychology Task Force of NIH Harmonization Consensus Conference
  • 2004–2010: Expert Panel Member to Develop Indicators for Telestroke
  • 2010: Alzheimer’s Disease Neuroimaging Study (ADNI) (A 60 million dollar NIH research project to serially image 800 individuals with Mild Cognitive Impairment, Alzheimer’s and healthy controls over 3 years.)
  • 2004–Present: Steering Committee
  • 2005–Present: Data & Publications Committee
  • 2003–Present: Telestroke Working Group
  • 2002–2010: Ex officio Board of Directors of Heart and Stroke Foundation Center for Stroke Recovery
  • 2002–Present: Site Director Committee for the Heart and Stroke Foundation Center for Stroke Recovery
  • 2002–Present: Founding Member of International Society for Vascular Behavioural and Cognitive Disorders (Vas Cog)
  • 2001–Present: N&E GTA Regional Stroke Steering Committee
  • 2001–Present: Planning Committee for Canadian Colloquium on Dementia
  • 1998–Present: Canadian Stroke Consortium Research and Development Committee
  • 1997–Present: Member, Research Committee
  • 1996–Present: Editorial Board, Healthline Update, HSFO newsletter
  • 1993–Present: Canadian Stroke Consortium: Founding Member
  • 1993–Present: Canadian Consortium for Clinical Cognitive Research

Membership

  • 2010: American Academy of Neurology
  • 2010: American Association for the History of Medicine
  • 2010: American Heart Association/American Stroke Association
  • 2010: American Society of NeuroRehabilitation
  • 2010: American Neurological Association
  • 2010: American Stroke Association - Fellow of the Stroke Council
  • 2010: Behavioural Neurology Society
  • 2010: Canadian Association for Neurosciences
  • 2010: Canadian Congress Neurological Society
  • 2010: Canadian Medical Association
  • 2010: Canadian Neurological Society
  • 2010: Canadian Society for the History of Medicine
  • 2010: Canadian Stroke Consortium
  • 2010: Consortium of Canadian Centres for Clinical Cognitive Research (C5R)
  • 2010: Geriatric Neurology Section, American Academy of Neurology
  • 2010: International Neuropsychological Society
  • 2010: International Society for Magnetic Resonance in Medicine
  • 2010: International Society for the History of the Neurosciences
  • 2010: International Society for Vascular Behavioural and Cognitive Disorders
  • 2010: Ontario Medical Association
  • 2010: Organization for Human Brain Mapping
  • 2010: Royal College of Physicians and Surgeons of Canada
  • 2010: Society for Behavioural Cognitive Neurology
  • 2010: Society of Neuroscience

Distinctions and Awards

  • 2010: Weyerhauser Scholarship, 1965-1969
  • 2010: Varsity Fund National Admission Scholarship , University of Toronto, Awarded for undergraduate study 1965-1969
  • 2006: Deborah Ivy Christiani Brill Chair in Neurology, Dept of Medicine, University of Toronto, $2 million endowment 2006-present, 2,000,000
  • 2006: The Acenberg Award for research achievements, Rotman Research Institute, Baycrest
  • 2005: Most Meritorious Researcher, Department of Medicine, Research Committee, 2005-2006
  • 2001: Inaugural Mel Silverman Mentorship Award , Institute of Medical Sciences (School of Graduate Studies), University of Toronto, For outstanding service as mentor and role model to graduate students
  • 1997: The Acenberg Award for research achievements, Rotman Research Institute
  • 1997: Department of Medicine Research Award, Sunnybrook Health Sciences Centre
  • 1984: Awarded for postgraduate medical research training, Ontario Heart Foundation Fellowship
  • 1983: Awarded for postgraduate medical research training, Medical Research Council Fellowship (Declined)
  • 1983: Awarded for postgraduate medical research training, Ontario Heart Foundation Fellowship
  • 1979: Osler Medal, award, The American Association for the History of Medicine , Best student essay in the history of medicine
  • 1978: Irving Heward Cameron Undergraduate Scholarship in Surgery
  • 1978: Dr. N. N. Levine Award in Family and Community Medicine
  • 1977: Awarded for academic achievement in Medical School Walter F. Watkins Scholarship
  • 1976: Hannah Institute Summer Fellowship
  • 1974: Canada Council Doctoral Fellowship
  • 1973: Historical Research Training Scholarship, Wellcome
  • 1972: Commonwealth Scholarship for post-graduate study Award, Oxford University, 1969-1972
  • 1969: Senior Stick for best all round student , Victoria College
  • 1969: Moss Memorial Scholarship for "Best All Round Student in Faculty of Arts and Science", University of Toronto, Awarded for overall achievement
  • 1968: Joseph William Binning Scholarship, University of Toronto, Awarded for academic achievement in Biological and Medical Sciences
  • 1967: Lillian Massey Trebel Scholarship
  • 1966: Crow Memorial Scholarship
  • 1965: Ontario Scholarship

Research Projects

External

  • 2007–2012: Neuropsychological Profiles and Neuroanatomic Correlates of Limb Apraxia
    Collaborators: Roy EA, Black SE (Co-PI), Dixon M, Danckert J, Park N, Adams S, Hebert D.

    Sponsors: Heart and Stroke Foundation, 404,725

    $80,945/annum

  • 2007–2012: The Language Impairment In Progressive Aphasia: A Longitudinal Neuropsychological And Imaging Study
    Collaborators: Rochon E, Black SE (Co-PI), Levine B, Leonard C, Freedman M, Chow T, Tang-Wai D, Graham N.

    Sponsors: CIHR, 511,835

    $102,367/annum
  • 2007–2010: Validation of the NINDS VCI Neuropsychological Protocols
    Collaborators: Nyenhuis DL, Black SE (Co-PI), Pedelty LL, Beam C, Gao W, Zhou XJ, Stebbins GT, Stuss DT, Graham SJ, Lobaugh N, Gao FQ, Sahlas D.

    Sponsors: National Institutes of Health, 1,250,000 (USD)

    $1.25 million total US; site total $512,824 US
  • 2006–2008: The Role of Cytokine-Serotonin Interactions in Post-Stroke Depression
    Collaborators: KL Lanctôt, N Herrmann, SE Black (co-PI), DJ Sahlas, D Gladstone and JE Ween.

    Sponsors: Heart and Stroke Foundation, 120,000

    $60,000/annum
  • 2005–2008: In Vivo Characterization of Subcortical Vascular Cognitive Impairment Using Advanced High Field MR Techniques
    Collaborators: Black SE, Moody A, Stanisz G, Graham S, Lobaugh N, Sahlas J, Stuss D.

    Sponsors: Vascular Health & Dementia Initiative (Heart and Stroke Foundation of Canada (PG050297)/Alzheimer Society of Canada (VHD007)/CIHR/Pfizer (DOV78345)), 359,850

    $119,950/annum
  • 2003–2008: In Vivo Brain Mapping in the Dementias: A Longitudinal Brain-Behaviour Study with A Focus on Cerebrovascular Disease
    Collaborators: Black SE, Graham S, Stuss D, Stanisz G, Caldwell C, Sahlas DJ, Swartz R.

    Sponsors: CIHR, 917,530

    MOP13129. $181,306/annum plus $11,000 equipment.
  • 2006–2010: A Multi-Centre, Blinded, Randomized, Controlled Trial Compaing Different Regimens of the Antibiotics Doxycycline and Rifampin for Treatment of Alzheimer’s Disease
    Collaborators: Molloy W, Lewis D, Borrie MJ, Patterson C, Decoteau WE, Jarrett PG, Woo TK, Chivers R, MacKnight CR, Rockwood K, Heckman GA, Black SE (site PI), Guyatt GH.

    Sponsors: CIHR, 1,864,896

    DARAD. $1,864,896.00/total award; $34,760 site total projected
  • 2005–2009: ADNI (Alzheimer’s Disease Neuroimaging Initiative)
    Collaborators: Black SE (Site PI at Sunnybrook)

    Sponsors: National Institutes of Health, 300,000

    $75,000/annum projected

  • 2002–2009: Canadian Alzheimer’s Disease Quality of Life Study
    Collaborators: Naglie G (PI), Krahn, Ritvo, Irvine, Silberfeld, Streiner D, Black SE (Site PI), Freedman M, Beattie L, Bergman H, Borrie M, Hogan D, MacKnight C, Patterson C.

    Sponsors: CIHR, 1,002,202

    $27,491 site total; UHN: $123,649/annum 2002-2009; TRI: $54,584/annum 2004-2006
  • 2007–2008: Infrastructure Revision of the Collaborative Affect, Cognition and Behaviour Database Tool (ABC’s)
    Collaborators: Ween JE, Black S, Stuss DR.

    Sponsors: Ontario Stroke System, 70,000

  • 2007–2009: Correlations Between Novel Biochemical Markers and MRI Subcortical Hyperintensities (SH) in Patients with Vascular Cognitive Impairment
    Collaborators: Phillips A-M, Chan PC, Pettersen J, Black S.
    Institutions: Sunnybrook Health Sciences Centre

    Sponsors: Practice-Based Research Award, 10,414

  • 2007–2009: Theory of Mind in Alzheimer’s Disease and Frontotemporal Dementia
    Collaborators: Freedman M, Stuss D, Black SE, Binns M.

    Sponsors: OMHF, 149,784

    $74,892/annum

  • 2007–2009: The Relationship Between Neuropsychological Deficits and Hippocampal Volume in Coronary Artery Disease
    Collaborators: Lanctot KL, Herrmann N, Black SE, Oh PI.

    Sponsors: The Physicians’ Services Incorporated Foundation, 143,000

    $71,500/annum

  • 2007–2008: Context-Aware Mobile Devices and Wireless Services as Cognitive Aids for Senior Citizens
    Collaborators: Baecker R, Black SE, DeLara E, Rochon E, Ryan D.

    Sponsors: Bell University Laboratories at the University of Toronto, 75,000

  • 2007–2008: The Determinants of Safe Mobility in the Elderly who use Assistive Mobility Devices
    Collaborators: Zabjek K, McIlroy W, Gage W, Maki BE, Naglie G, Hill S, Black SE, Mihailidis A, Fernie GR.

    Sponsors: CIHR, 95,230

    47,615/annum
  • 2006–2009: Parietal and Temporal Contributions to the Neglect Syndrome
    Collaborators: Ferber S, Black SE.

    Sponsors: CIHR, 200,526

    66,843/annum

  • 2006–2009: Feasibility and Effects of Cardiac Rehabilitation for Individuals After Stroke
    Collaborators: Brooks D, McIlroy W, Oh P, Bayley M, Black S, Sahlas J.

    Sponsors: Heart and Stroke Foundation, 208,275

    69,425/annum
  • 2006–2009: The Personal Therapist: A Smart Ambulatory Monitoring System to Facilitate Recovery following Stroke
    Collaborators: Gage W, McIlory B, Zabjek K, Popovic M, Brooks D, Black SE.

    Sponsors: CIHR, 169,500

    56,500/annum
  • 2006–2009: Early Exercise Intervention After Stroke: Improving Cardiovascular Health, Functional Capacity and Sensorimotor Control
    Collaborators: McIlroy W, Brooks D, Black SE, Nudo R, Verrier M, Popovic S, Staines R, Graham S, Thompson C, Chen R, DJ Gladstone

    Sponsors: CIHR, 205,086

    68,362/annum
  • 2006–2008: Serotonergic Function and Behavioural and Psychological Symptoms of Frontotemporal Dementia
    Collaborators: Herrmann N, Lanctot KL, Black SE, Chow T, Freedman M.

    Sponsors: Alzheimer Society of Canada, 159,716

    79,858/annum
  • 2006–2008: Stroke Canada Optimization of Rehabilitation by Evidence - Implementation Trial (SCORE-IT)
    Collaborators: Graham I, Harrison MB, Bayley M, Wood-Dauphinee S, Barreca S, Black S, et al.

    Sponsors: Canadian Stroke Network

    $tba/annum
  • 2005–2010: Centre for Research Using Magnetic Resonance (Multiuser Maintenance/Equipment Grant)
    Collaborators: Graham S (PI), Black SE, Grady C, Joy M, McIlroy W, Plewes D, Stanisz G, Warner E, Wright G, Bronsill M.

    Sponsors: CIHR, 625,000

    $125,000/ annum
  • 2003–2008: Brain and Aging Group at the Rotman Research Institute
    Collaborators: Stuss DT (PI), Alain C, Binns MA, Black SE, Chow TW, Craik FI, Freedman M, Grady CL, Graham SJ, Hasher L, Levine BT, Lobaugh NJ, Mayberg HS, McIntosh AR, Moscovitch M, O'Craven K, Pantev C, Picton TW, Ryan JD, Stefurak TL, Tulving E, Winocur G.

    Sponsors: CIHR, 2,074,570

    $400,029/annum core funding and $74,425 for equipment
  • 2001–2008: Canadian Stroke Registry
    Collaborators: Kapral M and Silver F (Project Leaders), Gladstone DJ (site PI) and Black SE (Co-I) at Sunnybrook

    Sponsors: NCE Canadian Stroke Network, 420,000

    $60,000/annum

Education, Training and Employment History:

1983 (Jan) - 1984 (Dec)Post-graduate Research Fellowship Training: Studied neurobehavioural consequences of stroke and localization of cerebral function by C.T. and nuclear magnetic resonance imaging in association with Dr. Andrew Kertesz, University of Western Ontario, London.
1978 - 1982Neurology Training Program: University of Toronto. Straight Internship, Medicine, St. Michael's Hospital (1978-1979); Senior Assistant Resident, Medicine (R2), Sunnybrook Health Sciences Centre (1979-1980); Resident in Neurology at Sunnybrook Health Sciences Centre, St. Michael's Hospital, Wellesley Hospital and Hospital for Sick Children (1980-1981); Chief Resident in Neurology, Toronto General Hospital (1982); Resident, Clinical Neurophysiology, Toronto Western Hospital (1982).
1975 - 1978Medical School, University of Toronto.
1971 - 1975
BLitt/DPhil program, Oxford University. DPhil thesis entitled, “The analysis of spinal and cerebral nervous activity: The development of the concept of reflex action in its biological context, 1832-1906,” examined ideas about the neurological basis of behaviour in the 19th century (the work of Sherrington, Pavlov, and others). In 1975 permission was given to lapse from the Program in order to allow full time attendance at Medical School and continuation of thesis work on a part time basis.
1969 - 1970History and Philosophy of Science Program, Oxford University (MA equivalent).
1965 - 1969Biological and Medical Sciences, University of Toronto.

Research Training

University of Western Ontario, London, PD Fellow, 1983 - 84, Neurobehavioural consequences of stroke and localization of cerebral function by C.T. and nuclear MRI in association with Dr. Andrew Kertesz
American Board of Neurology and Psychiatry, 1984, Certification in Neurology Royal College of Physicians of Canada,1983, Fellowship in Neurology

Professional Development:

International Neuropsychological Society (INS) February 1-4, 2006, Boston, Mass.

Licensures and Certificates

Medical Licensure:

  • College of Physicians and Surgeons of Ontario: License #50165
Specialty Licensure:
  • 1984 Certification in Neurology, American Board of Neurology and Psychiatry.
  • 1983 Fellowship in Neurology, Royal College of Physicians of Canada.
View more Teaching

View more Previous Grants

View more Previous Committees

Contact

A-421, Cognitive Neurology
Sunnybrook Health Sciences Centre
2075 Bayview Avenue
Toronto, Ontario M4N 3M5 Phone: 416.480.4551 Email: sandra.black@sunnybrook.ca Fax: 416.480.4552